3-(Trifluoromethyl)phenol → HCID 12531892, compound

HRID 1704073Notes

Reaction equation

HRID 1704073 reaction equation
Br[CH:2]([C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:16][CH:15]=2)=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[F:24][C:25]([F:34])([F:33])[C:26]1[CH:27]=[C:28]([OH:32])[CH:29]=[CH:30][CH:31]=1>>[F:24][C:25]([F:33])([F:34])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH:2]([C:7]2[CH:12]=[CH:11][C:10]([O:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:16][CH:15]=3)=[CH:9][CH:8]=2)[C:3]([O:5][CH3:6])=[O:4])[CH:27]=1

Participants

3

Reactant 2

HCID 73763-(Trifluoromethyl)phenolHCID 20392606HCID 20392606, compound

Product 1

HCID 12531892HCID 12531892, compoundYield 88.1%

Procedure

In a manner similar to Example 16, 7.54 g of methyl α-bromo-α-[p-(p-tert-butylphenoxy)phenyl]acetate was treated with 4.05 g of m-trifluoromethylphenol to give 8.07 g of product as a pale yellow glass.

Sources & evidence

ORD record
ord-e95916408a544be89e4431b90d012244
Source dataset
uspto-grants-1978_11
Patent number
US04125729

Reaction notes

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