4-Chlorophenol → Methyl alpha-(p-chlorophenoxy)-alpha-[p-(alpha,alpha,alpha-trifluoro-m-tolyloxy)phenyl]acetate

Participants

Reaction Steps

In a manner similar to Example 16, 7.62 g of methyl α-bromo-α-[p-(α,α,α-trifluoro-m-tolyloxy)phenyl]acetate was reacted with 3.21 g of p-chlorophenol to give a gel which crystallized on trituration with 50 ml of petroleum ether (6.45 g). Recrystallization from 50 ml of hexane yielded a 5.8 g of a white solid, mp 79°-82° C.

Provenance & Evidence