Hydrochloric Acid → HCID 22761157, compound

Participants

Reaction Steps

To a solution of 8.5 g of methyl(α,α,α-trifluoro-p-tolyloxy){p-[(p-chlorophenoxy)methoxy]phenyl}acetic acid in 50 ml of ethanol is added a solution of 6 g of potassium hydroxide in 50 ml of water. The mixture is refluxed for 4 hours and while hot, is acidified with 10 ml of concentrated HCl. The mixture is chilled immediately and extracted with dichloromethane. The extract is washed with a solution of sodium chloride, dried (MgSO4) and the solvent is removed under reduced pressure. The residue is triturated with hexane containing small amounts of ether and dichloromethane and chilled to give 6.7 g of product as white crystals. The product is recrystallized by dissolving in 50 ml of benzene, filtering the solution and diluting the filtrate with 75 ml of hexane. Chilling and filtering gives 6.1 g of white crystals, mp 88°-89° C.

Provenance & Evidence