Potassium Iodide → HCID 131711326, compound

Participants

Reaction Steps

A mixture of 2.70 g of 3,4-dimethylphenol and 0.89 g of 60% sodium hydride-oil dispersion in 40 ml of tetrahydrofuran is stirred at room temperature for 1 hour. To the mixture is added 3.7 g of potassium iodide, 1 ml of hexamethylphosphoramide and dropwise a solution of 8.55 g of methyl bromo{p-[(p-chlorophenoxy)methoxy]phenyl}acetate in 30 ml of tetrahydrofuran. The mixture is refluxed for 18 hours and worked-up as described in Example 5 to give 10.4 g of a gum. Chromatography over silica gel with dichloromethane as eluent gives the product as a gum.

Provenance & Evidence