4-Chlorophenol → HCID 131711328, compound

Participants

Reaction Steps

As described in Example 5, a mixture of 2.52 g of p-chlorophenol, 0.785 g of 60% sodium hydride-oil dispersion, 3.60 g of potassium iodide and 7.8 g of methyl bromo{p-[2-(p-chlorophenoxy)ethoxy]phenyl}acetate in 70 ml of tetrahydrofuran are refluxed for 18 hours and worked up to give 8.6 g of oil. The oil is triturated with hexane to give 6.9 g of tan crystals. Two recrystallizations from methanol gives the product as white crystals, mp 97°-112° C.

Provenance & Evidence