Potassium Iodide → HCID 131711329, compound

Participants

Reaction Steps

As described in Example 5, a mixture of 2.74 g of 3-dimethylaminophenol, 0.80 g of 60% sodium hydride-oil dispersion, 3.32 g of potassium iodide, one ml of hexamethylphosphoramide and 8.0 g of methyl bromo{p-[2-(p-chlorophenoxy)ethoxy]phenyl}acetate in 70 ml of tetrahydrofuran is refluxed for 18 hours and worked up to give 8.34 g of a gum. The gum is chromatographed on silica gel with dichloromethane as eluent to give 6.8 g of solid. Trituration with hexane-ether gives 3.50 g of crystals. Recrystallization gives crystals, mp 100°-101° C.

Provenance & Evidence