4-(Trifluoromethyl)phenol → HCID 86736162, compound

HRID 1704117Notes

Reaction equation

HRID 1704117 reaction equation
Br[CH:2]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[F:25][C:26]([F:35])([F:34])[C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=1>>[CH3:6][O:5][C:3](=[O:4])[CH:2]([O:33][C:30]1[CH:31]=[CH:32][C:27]([C:26]([F:25])([F:34])[F:35])=[CH:28][CH:29]=1)[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 678744-(Trifluoromethyl)phenolHCID 22761172HCID 22761172, compound

Product 1

HCID 86736162HCID 86736162, compound

Procedure

As described in Example 44, 8.14 g of methyl bromo{p-[3-(p-chlorophenoxy)propoxy]phenyl}acetate is reacted with p-trifluoromethylphenol to give 7.7 g of off-white crystals. Recrystallization from methanol gives the product as white crystals, mp 83°-84° C.

Sources & evidence

ORD record
ord-afed89cc20934a63bb04a7944cdbb67b
Source dataset
uspto-grants-1978_11
Patent number
US04125732

Reaction notes

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