Potassium Iodide → HCID 131711343, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2.36 g of p-t-butylphenol in 3 ml of tetrahydrofuran is added 0.625 g of sodium hydride (60% dispersion in oil). After stirring under argon for 1 hour and heating at 50° C. for 20 minutes, 2.4 g of potassium iodide and 6.0 g of methyl bromo{p-[2-(p-chlorophenoxy)-1-methylethoxy]phenyl}acetate in 30 ml of tetrahydrofuran is added. The mixture is stirred and refluxed for 18 hours and poured into 300 ml of ice-water containing 3 ml of acetic acid. The mixture is extracted with dichloromethane and the extracts washed with saturated NaHCO3, 10% sodium thiosulfate and saturated sodium chloride solution. The dichloromethane extract is dried (MgSO4) and the solvent removed under reduced pressure to give 6.7 g of product as a gum. Chromatography over silica gel with dichloromethane as eluent gives 5.7 g of yellow gum.

Provenance & Evidence