Hydrochloric Acid → HCID 22761135, compound

Participants

Reaction Steps

A mixture of 6.4 g of methyl(p-tert.-butylphenoxy){p-[2-(p-chlorophenoxy)propoxy]phenyl}acetate, 4 g of potassium hydroxide, 35 ml of ethanol and 35 ml of water is refluxed for 4 hours. The mixture is acidified with concentrated HCl, cooled, diluted with water and extracted with dichloromethane. The extract is washed with saturated NaCl solution, dried (MgSO4) and the solvent removed under reduced pressure to give 5.7 g of gum. Crystallization from hexane-ether gives 4.5 g of white crystals. Recrystallization from chloroform-hexane gives the product as white crystals, mp 135°-138° C.

Provenance & Evidence