Aluminium lithium hydride → 2-(3,4-Methylenedioxyphenyl)ethyl 1-methycyclopropyl carbinol

HRID 1704159Notes

Reaction equation

HRID 1704159 reaction equation
[CH3:1][C:2]1([C:5]([CH:7]=[CH:8][C:9]2[CH:14]=[CH:13][C:12]3[O:15][CH2:16][O:17][C:11]=3[CH:10]=2)=[O:6])[CH2:4][CH2:3]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH2:16]1[O:15][C:12]2[CH:13]=[CH:14][C:9]([CH2:8][CH2:7][CH:5]([C:2]3([CH3:1])[CH2:3][CH2:4]3)[OH:6])=[CH:10][C:11]=2[O:17]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 537125712-(3,4-Methylenedioxyphenyl)vinyl 1-methylcyclopropyl ketone

Product 1

HCID 234557382-(3,4-Methylenedioxyphenyl)ethyl 1-methycyclopropyl carbinol

Procedure

2-(3,4-Methylenedioxyphenyl)ethyl 1-methylcyclopropyl carbinol [IV; Ar is 3,4-methylenedioxyphenyl, R is CH3 ] was prepared from 23.4 g. of 2-(3,4-methylenedioxyphenyl)vinyl 1-methylcyclopropyl ketone (Preparation A3) and 3.88 g. of lithium aluminum hydride according to the procedure described above in Preparation B1, affording 18.8 g., b.p. 120°-130° C. (0.003 mm.).

Workup

  1. customaffording 18.8 g

Sources & evidence

ORD record
ord-5ba040baad444af3a42c044be2cbdd35
Source dataset
uspto-grants-1978_11
Patent number
US04125714

Reaction notes

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