Aluminium lithium hydride → 2-(3,4-Dimethoxyphenyl)ethyl 1-ethylcyclopropyl carbinol

HRID 1704160Notes

Reaction equation

HRID 1704160 reaction equation
[CH2:1]([C:3]1([C:6]([CH:8]=[CH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH3:19])[CH:11]=2)=[O:7])[CH2:5][CH2:4]1)[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:19][O:18][C:12]1[CH:11]=[C:10]([CH2:9][CH2:8][CH:6]([C:3]2([CH2:1][CH3:2])[CH2:5][CH2:4]2)[OH:7])[CH:15]=[CH:14][C:13]=1[O:16][CH3:17]

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 54360198HCID 54360198, compound

Product 1

HCID 234557662-(3,4-Dimethoxyphenyl)ethyl 1-ethylcyclopropyl carbinol

Procedure

2-(3,4-Dimethoxyphenyl)ethyl 1-ethylcyclopropyl carbinol [IV; Ar is 3,4-(CH3O)2C6H3, R is C2H5 ] was prepared from 15 g. of 2-(3,4-dimethoxyphenyl)vinyl 1-ethylcyclopropyl ketone (Preparation A4) and 2.2 g. of lithium aluminum hydride according to the procedure described above in Preparation B1, affording 10 g., b.p. 148°-150° C. (0.01 mm.).

Workup

  1. customaffording 10 g

Sources & evidence

ORD record
ord-897fcff6abdc44649a840dc21423941e
Source dataset
uspto-grants-1978_11
Patent number
US04125714

Reaction notes

Loading…