HCID 54251209, compound → HCID 53903795, compound

Participants

Reaction Steps

A mixture of 28.3 g. (0.1 mole) of 6-(3,4-methylenedioxyphenyl)-3-hexenyl bromide and 21 g. (0.15 mole) of lithium ethylacetoacetate in 200 ml. of dimethylformamide was heated under nitrogen with stirring at 55°-60° C. for 2 days. The reaction mixture was concentrated in vacuo and the residue partitioned between water and methylene dichloride. The methylene dichloride layer was washed with 5% aqueous sulfuric acid, water, 5% aqueous sodium bicarbonate and water, and dried over anhydrous magnesium sulfate. The ether solution was concentrated to afford ethyl 2-acetyl-8-(3,4-methylenedioxyphenyl)-5-octenoate as a yellow oil, used directly in the following reaction.

Provenance & Evidence