Potassium Hydroxide → HCID 23467384, compound

HRID 1704179Notes

Reaction equation

HRID 1704179 reaction equation
[CH3:1][O:2][C:3](=O)[C@H:4]([CH2:9][CH:10]([CH3:12])[CH3:11])[NH:5][C:6](=O)[CH3:7].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:15].[OH-].[K+]>C(Cl)(Cl)Cl>[CH3:7][C:6]1[S:15][C:3]([O:2][CH3:1])=[C:4]([CH2:9][CH:10]([CH3:12])[CH3:11])[N:5]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 14817Phosphorus sulfide (P2S5)HCID 6950952Methyl N-acetyl-L-leucinate

Product 1

HCID 23467384HCID 23467384, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A one-liter three necked flash equipped with a stirrer, condenser, and heating mantle is charged with 10 g (0.052 mole) of N-acetylleucine methyl ester and 14.5 g (0.062 mole) of phosphorus pentasulfide in 250 ml of chloroform, and the reaction mixture is refluxed for 24 hours while care is taken to exclude moisture. The reaction mixture is then cooled and made basic with 200 ml of 10% potassium hydroxide.

Workup

  1. customA one-liter three necked flash equipped with a stirrer, condenser
  2. temperatureheating mantle
  3. temperaturethe reaction mixture is refluxed for 24 hours while care
  4. temperatureThe reaction mixture is then cooled

Sources & evidence

ORD record
ord-a91aa80cd74444508b25d171ae158069
Source dataset
uspto-grants-1978_11
Patent number
USRE029843

Reaction notes

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