Potassium Hydroxide → 5-Ethoxy-2-methyl-4-(2-methylpropyl)thiazole

HRID 1704181Notes

Reaction equation

HRID 1704181 reaction equation
[CH2:1]([O:3][C:4](=O)[C@H:5]([CH2:10][CH:11]([CH3:13])[CH3:12])[NH:6][C:7](=O)[CH3:8])[CH3:2].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:16].[OH-].[K+]>C(Cl)(Cl)Cl>[CH3:8][C:7]1[S:16][C:4]([O:3][CH2:1][CH3:2])=[C:5]([CH2:10][CH:11]([CH3:13])[CH3:12])[N:6]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 14817Phosphorus sulfide (P2S5)HCID 1549286HCID 1549286, compound

Product 1

HCID 227589445-Ethoxy-2-methyl-4-(2-methylpropyl)thiazole

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A one liter three-neck flask equipped with a stirrer, condenser, and heating mantle is charged with 31.4 g (0.156 mole) of N-acetylleucine ethyl ester, 34.7 g (0.156 mole) of phosphorus pentasulfide, and 250 ml of chloroform, and the mixture is heated under reflux for 24 hours while care is taken to exclude moisture. The reaction mixture is then cooled and made basic with 10% aqueous potassium hydroxide.

Workup

  1. customA one liter three-neck flask equipped with a stirrer, condenser
  2. temperatureheating mantle
  3. temperaturethe mixture is heated
  4. temperatureunder reflux for 24 hours while care
  5. temperatureThe reaction mixture is then cooled

Sources & evidence

ORD record
ord-5fe4ce41940e4c1d9dbd8a1d99c88bba
Source dataset
uspto-grants-1978_11
Patent number
USRE029843

Reaction notes

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