HuagongsheHuagongshe Chemistry Print Report · For research reference only
2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- → N-[(1R,2R)-2-cyclohexylcyclopentyl]piperidin-2-imine;hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- | HCID 75657 | — |
| Reactant | o-Methylvalerolactim | HCID 138567 | — |
| Reactant | cis-2-Cyclohexylcyclopentylamine hydrochloride | HCID 70050481 | — |
| Reactant | rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochloride | HCID 70051154 | — |
| Product | N-[(1R,2R)-2-cyclohexylcyclopentyl]piperidin-2-imine;hydrochloride | HCID 145795656 | — |
Reaction Steps
Following the procedure of Example 1, only substituting for cis-2-phenylcyclopentylamine hydrochloride and O-methylcaprolactim, appropriate amounts of cis-2-(cyclohexyl)cyclopentylamine hydrochloride and O-methylvalerolactim respectively the desired product was obtained. M.P. 195.5°-197° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04126612 |
| Source dataset | uspto-grants-1978_11 |
| ORD ID | ord-52a537e29df6415694df0fee111872d3 |
| Source note | uspto-grants-1978_11 |