反应详情

A mixture of 4.0 g of cis-2-phenylcyclopentylamine hydrochloride, M.P. 205°-206° C. and 5.0 ml of O-methylcaprolactim was allowed to stand at room temperature for 6 days with occasional stirring. A few drops of ethanol were added to maintain a stirrable slurry, after which the mixture was cooled. The resulting solid was washed with ether and recrystallized from acetone/methanol to give the desired product, M.P. 181.5°-183.5° C. (dec.).

1. temperatureto maintain a stirrable slurry
2. temperatureafter which the mixture was cooled
3. washThe resulting solid was washed with ether
4. customrecrystallized from acetone/methanol