Sodium Hydroxide → HCID 22759232, compound

HRID 1704348Notes

Reaction equation

HRID 1704348 reaction equation
[C:1]([C:4](C(OCC)=O)([CH2:15][CH2:16][CH2:17][CH:18]([O:28]C(=O)C)[CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=1)[CH2:5][C:6]#[C:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]C)=[O:12])(=[O:3])[CH3:2].[OH-].[Na+]>O.CO>[C:1]([CH:4]([CH2:15][CH2:16][CH2:17][CH:18]([OH:28])[CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=1)[CH2:5][C:6]#[C:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 22759338HCID 22759338, compound

Product 1

HCID 22759232HCID 22759232, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Methyl 8-acetyl-8-ethoxycarbonyl-12-acetoxy-13-(4-fluorophenoxy)-5-tridecynoate (40.00 g., 0.079 mole) is added to a solution of sodium hydroxide (18.96 g.; 0.474 mole) in water (132.7 ml.) and methanol (462.9 ml.). The resulting solution is allowed to stand for 191/2 hours at 55°.

Workup

  1. custom2 hours
  2. customat 55°

Sources & evidence

ORD record
ord-ad40c453d27147ddbcda54fb3bf857c0
Source dataset
uspto-grants-1978_11
Patent number
US04126629

Reaction notes

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