Ethanol → Ethyl 4-chloroacetoacetate

Participants

Reaction Steps

72 g (1 mol) of chlorine were passed into a solution of 84 g (1 mol) of diketene in dry carbon tetrachloride at -20° C and the reaction solution was then added dropwise, while stirring, to 200 ml of ethanol, during which addition the temperature was not allowed to rise above 0° C. The solvent was then stripped off in vacuo on a rotary evaporator and the residue was distilled. 155 g (94% of theory) of γ-chloroacetoacetic acid ethyl ester of boiling point 90° C/7 mm Hg were obtained.

Provenance & Evidence