HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → Ethyl 4-(2-pyrimidinylimino)-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 2-Aminopyrimidine | HCID 7978 | — |
| Reactant | Ethyl 4-oxo-1-piperidinecarboxylate | HCID 34767 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 4-(2-pyrimidinylimino)-1-piperidinecarboxylate | HCID 21460901 | — |
Reaction Steps
A mixture of 34 parts of ethyl 4-oxo-1-piperidinecarboxylate, 20 parts of 2-pyrimidinamine, 8 drops of acetic acid and 90 parts of methylbenzene is stirred and refluxed for 28 hours with water-separator. The reaction mixture is evaporated, yielding 50 parts of ethyl 4-(2-pyrimidinylimino)-1-piperidinecarboxylate as a residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04126689 |
| Source dataset | uspto-grants-1978_11 |
| ORD ID | ord-79dc180667ed4a91a6f0d88bab9bcfc0 |
| Source note | uspto-grants-1978_11 |