HCID 21829171, compound → Pyridine, 2,3,5-trichloro-

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Reaction Steps

A solution was prepared by dissolving 2.5 grams of 2,3,5-trichloro-4-hydrazinopyridine in 25 milliliters of tetrahydrofuran. To this mixture was added ~10 milliliters of 5.25 percent sodium hypochlorite. The mixture was stirred at ~30° C. for about one hour. The mixture was diluted with water and extracted with methylene chloride. The extract was washed with water and the methylene chloride removed by evaporation. The residue, a dark brown oil, was recovered in a yield of 2.1 grams. The crude 2,3,5-trichloropyridine product was sublimed at ~1 millimeter of mercury and ~50° C. The purified product was obtained in a yield of 1.52 grams (72 percent of theoretical). The structure was confirmed by N.M.R.

Provenance & Evidence