Acetic Acid → HCID 12468024, compound

HRID 1704643Notes

Reaction equation

HRID 1704643 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7]1=[N:11][C:12]([CH3:14])=[N:13][N:6]1[C:5]2([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)N.C(O)(=[O:24])C>CO>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([C:7]2[N:11]=[C:12]([CH3:14])[NH:13][N:6]=2)=[C:4]([CH:3]=1)[C:5]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:24]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 124680237-Chloro-2-methyl-5-phenyl-5H-[1,2,4]triazolo[5,1-a]isoindol-5-amine

Product 1

HCID 12468024HCID 12468024, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ten milligrams of 7-chloro-2-methyl-5-phenyl-5H-[1,2,4]triazolo-[5,1-a]-isoindol-5-amine (as prepared in Example 1) are refluxed for 10 minutes in 2 ml of 50% aqueous methanol containing a drop of acetic acid. The methanol is removed under vacuum and the aqueous residue made basic with 10% NaOH. The aqueous solution is washed with chloroform, neutralized with 10% HCl and extracted with chloroform. The chloroform solution is evaporated to dryness and the residue is recrystallized from a water-ethanol mixture, m.p. 149° to 150°.

Workup

  1. customThe methanol is removed under vacuum
  2. washThe aqueous solution is washed with chloroform
  3. extractionextracted with chloroform
  4. customThe chloroform solution is evaporated to dryness
  5. customthe residue is recrystallized from a water-ethanol mixture, m.p. 149° to 150°

Sources & evidence

ORD record
ord-0ef3825a6c99435f97e2425fff98bfb6
Source dataset
uspto-grants-1978_11
Patent number
US04127587

Reaction notes

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