反应详情

Ten milligrams of 7-chloro-2-methyl-5-phenyl-5H-[1,2,4]triazolo-[5,1-a]-isoindol-5-amine (as prepared in Example 1) are refluxed for 10 minutes in 2 ml of 50% aqueous methanol containing a drop of acetic acid. The methanol is removed under vacuum and the aqueous residue made basic with 10% NaOH. The aqueous solution is washed with chloroform, neutralized with 10% HCl and extracted with chloroform. The chloroform solution is evaporated to dryness and the residue is recrystallized from a water-ethanol mixture, m.p. 149° to 150°.

1. customThe methanol is removed under vacuum
2. washThe aqueous solution is washed with chloroform
3. extractionextracted with chloroform
4. customThe chloroform solution is evaporated to dryness
5. customthe residue is recrystallized from a water-ethanol mixture, m.p. 149° to 150°