HCID 131710974, compound → HCID 131710973, compound

HRID 1704687Notes

Reaction equation

HRID 1704687 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH3:7][N:8]([CH3:42])[CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH2:19][N:20]([CH2:31][CH2:32][C:33]1[CH:38]=[CH:37][C:36]([N+:39]([O-])=O)=[CH:35][CH:34]=1)[C:21](=[O:30])[CH:22]=[CH:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[H][H]>C(O)C.[Pd]>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[NH2:39][C:36]1[CH:37]=[CH:38][C:33]([CH2:32][CH2:31][N:20]([CH2:19][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[O:12][CH2:11][CH2:10][CH2:9][N:8]([CH3:42])[CH3:7])[C:21](=[O:30])[CH:22]=[CH:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:34][CH:35]=1

Participants

5

Reactant 2

HCID 131710974HCID 131710974, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 131710973HCID 131710973, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 10 parts of N-[[2-[3-(dimethylamino)-propoxy]phenyl]methyl]-N-[2-(4-nitrophenyl)ethyl]-3-phenyl-2-propenamide, oxalate salt (1:1) in 100 ml of ethanol is treated with 1 part of 5% palladium on carbon and placed under 3 atmospheres of gaseous hydrogen. The mixture is shaken until one equivalent of hydrogen is consumed, filtered and the solvent evaporated under reduced pressure to give the title compound.

Workup

  1. customis consumed
  2. filtrationfiltered
  3. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-4d6ef27a7157405482c019b67c07c039
Source dataset
uspto-grants-1978_11
Patent number
US04127606

Reaction notes

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