4-Acetylbutyric acid → HCID 13839457, compound

Participants

Reaction Steps

As shown in Table B, 5-ketohexanoic acid IX was reacted with thionyl chloride. The reaction mixture yielded 5-ketohexanoylchloride X which was recovered after distillation. The 5-ketohexanoyl chloride X intermediate was reacted with acetylene and aluminum chloride and converted into the chloro-diketone compound XI. The diketone compound was converted into the corresponding iodovinyl diol XIII by adding to the reaction mixture sodium iodide in a solvent such as acetone, and reducing the intermediate compound XII to the diol by adding sodium borohydride.

Provenance & Evidence