Ammonia → HCID 54243497, compound

Participants

Reaction Conditions

Reaction Steps

28 ml of triethylamine was dissolved in 600 ml of chloroform, then 49g of 3-(3,4-dichlorobenzoyl)acrylic acid was added. The resulting solution was cooled to 0° C., and 42g of ethyl cloroformate was added. The mixture was warmed to 20° C., stirred for one hour, cooled to 0° C. and then held there while gaseous ammonia was passed into the solution until no further heat of reaction was noted. A precipitate that formed was collected, washed with water and then with acetone to give 4-(3,4-dichlorophenyl)-4-oxo-2-butenamide (4A), as a white solid, m.p.: 208° C. (with decomposition).

Provenance & Evidence