Water → HCID 21333356, compound

HRID 1704724Notes

Reaction equation

HRID 1704724 reaction equation
[C:1]1([C:7]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:8]2[CH:9]=[CH:10][C:11]([C:14]#[N:15])=[N:12][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH2:28].[OH-].[K+]>CO>[C:16]1([C:7]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:8]2[CH:9]=[CH:10][C:11]([C:14]([NH2:15])=[O:28])=[N:12][CH:13]=2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 21333323HCID 21333323, compound

Product 1

HCID 21333356HCID 21333356, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dissolve 5 g. of 5-(triphenylmethyl)-2-cyanopyridine in a mixture consisting of 50 ml. of water and 1.0 liter of methanol. Add 4 g. of potassium hydroxide and heat the mixture at reflux for fifteen (15) hours. Remove the methanol under reduced pressure, triturate the residue with water and dry the solids obtained thereby. Crystallize the product from acetonitrile to obtain the product of this example. m.p. 239°-240° C.

Workup

  1. dissolutionDissolve 5 g
  2. additionAdd 4 g
  3. customRemove the methanol under reduced pressure
  4. customtriturate the residue with water
  5. customdry the solids
  6. customobtained
  7. customCrystallize the product from acetonitrile
  8. customto obtain the product of this example

Sources & evidence

ORD record
ord-106a825ec22440f5a6be4b2e36b86945
Source dataset
uspto-grants-1978_11
Patent number
US04127662

Reaction notes

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