Thiophenol → 3-Chloropropyl phenyl sulfide

Participants

Reaction Steps

A mixture of thiophenol (1 mole), sodium hydroxide (1 mole) and 3-bromo-1-chloro-propane (2 moles) in water (1000 ml) and ethanol (250 ml) is refluxed duting 20 hours, with stirring. After cooling, sodium hydroxide (30 g) is added to the reaction medium which is then extracted with methylene chloride. The organic phase is washed with water to neutral pH, after which it is dried over sodium sulfate, concentrated and distilled. B.p. = 165° C./15 mm Hg. N.M.R.: consistent.

Provenance & Evidence