Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chloroacetonitrile | HCID 7856 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-hydroxychromen-4-one | HCID 5174122 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22758704 | HCID 22758704 | 94% |
Reaction Steps
A mixture of 3-hydroxychromone (4.86 g, 0.03 mole), chloroacetonitrile (2.26 g, 0.03 mole) and potassium carbonate (3.0 g, 0.02 mole) in dimethylformamide (40 ml) is stirred at 100° C. under nitrogen for 4 hrs. The reaction mixture is cooled, poured into water (200 ml), filtered, washed with water and sucked dry. Recrystallization from methanol gives white crystals (4.7 g, 94%), mp 145°-146° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04127669 |
|---|
| Source dataset | uspto-grants-1978_11 |
|---|
| ORD ID | ord-299c6f92704a4b64af2358588f1f2a65 |
|---|
| Source note | uspto-grants-1978_11 |
|---|
