Methanol → HCID 12421619, compound

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Reaction Steps

A mixture of 8-methoxy-3-(methylsulfinyl)chromanone (20 g), methanol (100 ml) and 1N hydrochloric acid (100 ml) is stirred at room temperature for 20 hrs. The methanol is removed at reduced pressure and the aqueous residue is extracted with chloroform. The chloroform extracts are combined, extracted with 1N sodium hydroxide solution, washed with water, dried over MgSO4 and evaporated to give an oil. The oil is heated at 100° C. in 5N hydrochloric acid (100 ml) for 5 hrs. The solution is cooled and the product which precipitated is filtered off. Recrystallization from ethanol gives 8-methoxy-3-(methylthio)chromone (2) as white crystals (12.1 g, 65%), mp 113°-115° C.

Provenance & Evidence