N,N-Dimethyl-1,3-propanediamine → 8-ethyl-5-(dihydropyridazin-1-yl)-8H-pyrazolo[4',3':5,6]pyrido[3,4-e]-[1,2,4]triazolo[1,5-a]pyrimidine

HRID 1704770Notes

Reaction equation

HRID 1704770 reaction equation
[NH:1]1[CH:6]=[CH:5][CH:4]=[CH:3][NH:2]1.CN(C)CCCN.[C:14]([N:22]1[C:26]2[N:27]=[CH:28][C:29]3[C:30](OC4C=CC=CC=4)=[N:31][C:32]4[N:33]([N:35]=[CH:36][N:37]=4)[C:34]=3[C:25]=2[CH:24]=[N:23]1)(=O)[C:15]1C=CC=CC=1>>[CH2:14]([N:22]1[C:26]2[N:27]=[CH:28][C:29]3[C:30]([N:1]4[CH:6]=[CH:5][CH2:4][CH2:3][NH:2]4)=[N:31][C:32]4[N:33]([N:35]=[CH:36][N:37]=4)[C:34]=3[C:25]=2[CH:24]=[N:23]1)[CH3:15]

Participants

4

Reactant 3

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 426233DihydropyridazineHCID 227585058-Benzoyl-5-phenyloxy-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine

Product 1

HCID 227585068-ethyl-5-(dihydropyridazin-1-yl)-8H-pyrazolo[4',3':5,6]pyrido[3,4-e]-[1,2,4]triazolo[1,5-a]pyrimidine

Procedure

By substituting dihydropyridazine for the 3-(dimethylamino)propylamine in the procedure of Example 1 (c), 8-ethyl-5-(dihydropyridazin-1-yl)-8H-pyrazolo[4',3':5,6]pyrido[3,4-e]-[1,2,4]triazolo[1,5-a]pyrimidine is obtained.

Sources & evidence

ORD record
ord-ff7b03b5a138446dbecf38cb7ea192fe
Source dataset
uspto-grants-1978_11
Patent number
US04127655

Reaction notes

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