反应详情

温度

110 °C

An autoclave was charged with 1.54 g. (0.01 mole) of 7-amino[1,2,5]thiadiazolo[3,4-d]pyrimidine prepared by the process set forth in Example 1, 5.1 g. (0.3 mole) ammonia and 4.48 g. (0.025 mole) 2-chloro-6-fluorobenzyl chloride. The vessel was sealed and the contents heated at 110° C. for 15 hours. After cooling and evaporation of the excess ammonia, the resulting solid was collected by filtration, washed successively with water and hexane to afford a 25% yield of product.

1. additionAn autoclave was charged with 1.54 g
2. customThe vessel was sealed
3. temperatureAfter cooling
4. customevaporation of the excess ammonia
5. filtrationthe resulting solid was collected by filtration
6. washwashed successively with water and hexane