反应详情

A mixture of 2-methyleneglutaric acid [Ber. 34, 427 (1901)] (40 g.) and acetyl chloride (80 ml.) is heated on the steam bath for 1.5 hours. The excess acetyl chloride is removed in vacuo (75°) and the residue is evaporated from toluene twice. Finally, the residue is dissolved in ethanol and heated on the steam bath for one hour. The reaction mixture is concentrated to dryness to yield 2-methylene-4-(ethoxycarbonyl)butyric acid.

1. temperatureis heated on the steam bath for 1.5 hours
2. customThe excess acetyl chloride is removed in vacuo (75°)
3. customthe residue is evaporated from toluene twice
4. dissolutionFinally, the residue is dissolved in ethanol
5. temperatureheated on the steam bath for one hour
6. concentrationThe reaction mixture is concentrated to dryness