HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-Oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate | HCID 13851097 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic Acid | HCID 22758827 | — |
Reaction Steps
A mixture of ethyl 4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (2.78 g., 0.010 mole), 1.0 N NaOH (15.0 ml.), H2O (40 ml.) and ethanol (30 ml.) was refluxed for 15 minutes. The mixture was filtered and the cooled filtrate acidified with 15.0 ml. of 1.0 N HCl to precipitate crude acid (2.36 g.), m.p. 193°-223°. Two recrystallizations from 2-methoxyethanol gave peach needles, m.p. 252°-253.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04127720 |
| Source dataset | uspto-grants-1978_11 |
| ORD ID | ord-a59d824971bf4c57bb5dc76074e0fe98 |
| Source note | uspto-grants-1978_11 |