HCID 22758847, compound → HCID 22758843, compound

Participants

Reaction Steps

A mixture of ethyl (±)-7-allyl-6,7-dihydro-10-methoxy-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (190 mgs.) in p-cymene (5 ml.) containing 10% palladium on carbon (50 mgs.) was refluxed for 4 hours. The mixture was cooled, diluted with methylene chloride and filtered to remove the catalyst. The filtrate was evaporated to dryness in vacuo and the residue recrystallized from ethanol, with charcoal treatment, to give yellow needles of title product (119 mgs., 63%), m.p. 187°-188°.

Provenance & Evidence