HCID 22758855, compound → HCID 22758808, compound

Participants

Reaction Steps

A solution of ethyl 10-methoxy-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (3.0 g., 0.010 mole) in a mixture of acetic acid (45 ml.) and 37% hydrochloric acid (23 ml.) was refluxed for 45 minutes. The mixture was cooled, diluted with water, and the yellow solid collected and dried to give the title acid: 2.6 g.(96% yield) m.p. 261°-263°. Recrystallization from acetic acid followed by n-butyl acetate gave the analytical sample, m.p. 262°-264°.

Provenance & Evidence