HCID 22758832, compound → HCID 22758833, compound

HRID 1704829Notes

Reaction equation

HRID 1704829 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]1=[N:15][CH:16]=[C:17]([C:20]([NH2:22])=O)[C:18](=[O:19])[N:8]1[CH2:7][CH2:6]2>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]1=[N:15][CH:16]=[C:17]([C:20]#[N:22])[C:18](=[O:19])[N:8]1[CH2:7][CH2:6]2

Participants

3

Reactant 1

HCID 22758832HCID 22758832, compound

Product 1

HCID 22758833HCID 22758833, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In a manner similar to that described in Example 23B, 6,7-dihydro-9,10-dimethoxy-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxamide was dehydrated to the nitrile in 93% yield, m.p. 261°-262° from acetic acid.

Sources & evidence

ORD record
ord-9d53168416da47028bef6af4d23636e1
Source dataset
uspto-grants-1978_11
Patent number
US04127720

Reaction notes

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