HCID 22758833, compound → HCID 178486500, compound

HRID 1704830Notes

Reaction equation

HRID 1704830 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]1=[N:15][CH:16]=[C:17]([C:20]#[N:21])[C:18](=[O:19])[N:8]1[CH2:7][CH2:6]2.[NH:22]1C=N[N:24]=[N:23]1>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]1=[N:15][CH:16]=[C:17]([C:20]3[NH:24][N:23]=[N:22][N:21]=3)[C:18](=[O:19])[N:8]1[CH2:7][CH2:6]2

Participants

4

Reactant 2

HCID 22758833HCID 22758833, compoundHCID 178418441HCID 178418441, compound

Product 1

HCID 178486500HCID 178486500, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In a manner similar to that described in Example 23C, 6,7-dihydro-9,10-dimethoxy-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carbonitrile was converted to the corresponding tetrazole in 57% yield, m.p. 286°-288° (decomp) from acetic acid.

Sources & evidence

ORD record
ord-8437076f4112415da50fa71b1e8ae3e0
Source dataset
uspto-grants-1978_11
Patent number
US04127720

Reaction notes

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