HCID 22758817, compound → HCID 22758834, compound

Participants

Reaction Steps

A stirred mixture of (±)-7-ethyl-6,7-dihydro-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carbonitrile (3.5 g.) and 10% palladium on carbon (1.5 g.) in p-cymene (50 ml.) was refluxed for 18 hours. The mixture was diluted with methylene chloride and filtered to remove the catalyst. The solvents were removed on a rotary evaporator and the residue crystallized from ethanol to give 1.6 g. (46% yield) of the title compound, m.p. 208°-211°. Successive recrystallizations from toluene and ethanol provided the analytical sample, m.p. 218°-219°.

Provenance & Evidence