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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 170565Generated: October 25, 2026

Water → 3-chloro-N-[2-hydroxy-5-(trifluoromethoxy)phenyl]isonicotinamide

https://huagongshe.com/reaction/170565

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantDimethylformamideHCID 6228—
ReactantTriethylamineHCID 8471—
ReactantHexafluorophosphateHCID 9886—
ReactantBenzotriazol-1-yloxy-tris(dimethylamino)phosphoniumHCID 124335—
Reactant3-Chloropyridine-4-carboxylic acidHCID 2735816—
Reactant2-Amino-4-(trifluoromethoxy)phenolHCID 2737729—
Product3-chloro-N-[2-hydroxy-5-(trifluoromethoxy)phenyl]isonicotinamideHCID 66880033—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
ORD IDord-734faf12a8c5493082c1b72deaad3e12
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (9/10)