3,5-Dimethylpyrazole → HCID 22811195, compound

Participants

Reaction Steps

1-Benzyloxycarbonyl-4-benzyloxy-L-proline (4.55 g.) [obtained from 4-benzyloxyproline [Biochem. Biophys. Acta 303, 198 (1973)] and benzyloxycarbonyl chloride] and 3,5-dimethylpyrazole (1.15 g.) are dissolved in chloroform (200 ml.). Dicyclohexylcarbodiimide (2.06 g.) is added and the mixture is stirred in an ice-salt bath for one hour and at room temperature for 16 hours. The precipitate is filtered and the filtrate is concentrated to dryness. The residue is dissolved in ethyl acetate, washed with N-hydrochloric acid and water. The organic layer is dried and concentrated to dryness in vacuo to yield 1-benzyloxycarbonyl-4-benzyloxy-L-proline-3,5-dimethylpyrazolide.

Provenance & Evidence