Potassium Hydroxide → HCID 20336519, compound

HRID 1706016Notes

Reaction equation

[CH3:1][N:2]([CH3:26])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[C:8]([CH3:25])=[N:9][C:10]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:11][C:12]=1[C:13]([O:15]CC)=[O:14].[OH-].[K+]>>[CH3:26][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[C:8]([CH3:25])=[N:9][C:10]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:11][C:12]=1[C:13]([OH:15])=[O:14]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 20336513HCID 20336513, compound

Product 1

HCID 20336519HCID 20336519, compound

Procedure

Hydrolysis of 2-methyl-4-carbethoxy-6-benzyl-pyridin-3-yl 3-dimethylaminopropyl ether (Example 19) with methanolic potassium hydroxide solution at 60° C. gives 2-methyl-4-carboxy-6-benzyl-pyridin-3-yl 3-dimethylaminopropyl ether, of melting point 157° C. N determination: calculated 8.5%, found 8.6%.

Sources & evidence

ORD record: ord-12d96fc52cbc4df7b794c11e127585d6
Source dataset: uspto-grants-1980_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04206117

Reaction notes

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