1-[3-acetylthio-2-(methylthiomethyl)propanoyl]-L-proline → [3-mercapto-2-(methylthiomethyl)propanoyl]-L-proline

Participants

Reaction Steps

1-[3-(acetylthio)-2-(methylthiomethyl)propanoyl]-L-proline (1.2 g.) is dissolved in a mixture of water (12 ml.) and concentrated ammonia (12 ml.) under a blanket of argon. After twenty minutes, the reaction mixture is acidified and extracted with ethyl acetate. The organic layer is dried and concentrated to dryness to yield 1-([3-mercapto-2-(methylthiomethyl)propanoyl]-L-proline.

Provenance & Evidence