HCID 20337273, compound → HCID 20337260, compound

HRID 1706138Notes

Reaction equation

HRID 1706138 reaction equation
[CH3:1][S:2][C:3]1[C:13]2[CH2:12][CH2:11][NH:10][CH2:9][CH:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:7]=2[CH:6]=[C:5]([OH:20])[C:4]=1[OH:21]>CO>[CH3:1][S:2][C:3]1[C:4](=[O:21])[C:5](=[O:20])[CH:6]=[C:7]2[C:13]=1[CH2:12][CH2:11][NH:10][CH2:9][CH:8]2[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 1

HCID 20337273HCID 20337273, compound

Product 1

HCID 20337260HCID 20337260, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-Methylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (5 g) is oxidized with 2,3-dichloro-4,5-dicyano-1,4-benzoquinone in methanol at room temperature as in Example 1 to give 6-methylthio-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-dione which (1 g) is reacted with methylmercaptan in methanol to give 6,9-dimethylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

Sources & evidence

ORD record
ord-84eaf7c31e1643ccb615d79ad900e3c3
Source dataset
uspto-grants-1980_06
Patent number
US04206210

Reaction notes

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