Toluene → HCID 20337373, compound

Participants

Reaction Steps

44 g of 5-chloro-3-(4'-chloromethylphenyl)-1,2-benzisothiazole, 9.6 g of sulfur and 22.5 g of 1,2-diaminopropane in 600 ml of toluene are refluxed for 24 hours. The reaction mixture is filtered hot and the filtrate is concentrated on a rotary evaporator. The residue is dissolved in 500 ml of ether and 30 g of hydrogen chloride gas are passed into the solution, whilst cooling. The resulting crystals are filtered off and recrystallized from water. 31 g of product melting, with decomposition, at 248° C., are obtained. The yield corresponds to 57% of theory.

Provenance & Evidence