2-Methyl-2-thiopseudourea sulfate → HCID 20185723, compound

Participants

Reaction Steps

A mixture of 3-(N-hydroxyamino)propylphosphonic acid (1.64 g.) in 1 N aqueous sodium hydroxide solution (10 ml.) and S-methylisothiourea sulfate (1.40 g.) in water (5 ml.) was heated to reflux for 1.5 hours and allowed to stand overnight at ambient temperature to give crystalline precipitates, which was collected by filtration and washed with water and then with ethanol to give 3-(1-hydroxyguanidino)propylphosphonic acid (690 mg.), mp: 244°-247° C. (dec.).

Provenance & Evidence