Water → HCID 20337466, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2,5-dimethoxyphenyl)propyl 2-phenylethyl ether (195 mg., 0.65 mM), pyridine (0.4 ml., 4.96 mM) and dry pyridine hydrochloride (4 g., 34.6 mM) is heated at 190° C. for 6 hours. The reaction mixture is cooled and added to a mixture of water (100 ml.) and ether (150 ml.). The ether extract is washed once with water (50 ml.) and, along with a second ether extract (50 ml.) of the aqueous phase, is dried over magnesium sulfate and evaporated to dryness. The residue is purified via preparative layer chromatography on silica gel plates by elution with ether-pentane.

Provenance & Evidence