Ethanol → Ethyl phenylacetate

Participants

Reaction Steps

To a CH2Cl2 (2 ml) solution of 2,6-dichloro-1-ethylpyridinium tetrafluoroborate (630 mg, 2.4 mmol) was added a mixture of ethyl alcohol (92 mg, 2.0 mmol), phenylacetic acid (272 mg, 2.0 mmol) and tri-n-butylamine (888 mg, 4.8 mmol) in CH2Cl2 (2 ml), and the resulting mixture was refluxed for 3 hours. After evaporation of the solvent, the residue was separated by silica gel column chromatography, and ethyl phenylacetate was isolated in 90% yield.

Provenance & Evidence