HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 131711784, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- | HCID 83170 | — |
| Reactant | 3a,4,7,7a-Tetrahydro-2-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione | HCID 89529 | — |
| Reactant | HCID 131711782 | HCID 131711782 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131711784 | HCID 131711784 | — |
Reaction Steps
Boc-Nle-Asn-Thr-OBzl (3.50 g) was treated with TFA (30 ml) and the solvent was evaporated. The residue was triturated with ether to give powders, which were dissolved in DMF (30 ml) together with TEA (1.2 ml). To this was added Boc-Leu-ONB which was prepared from Boc-Leu-OH (1.66 g), HONB (1.41 g) and DCC (1.63 g). The mixture was stirred at room temperature for 15 hours and the solvent was evaporated. The residue was triturated with water (50 ml) to give powders, which were collected by filtration and washed with ethyl acetate. Yield 3.60 g (83.8%); m.p. 200°-201° C. [α]D21.5 -22.7° (c=0.8, DMF), Rf1 0.60
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04206199 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-5651d9d0f107447996c97735724134de |
| Source note | uspto-grants-1980_06 |