Acetic Acid → HCID 15099411, compound

Participants

Reaction Steps

5 g of 1-benzyl-2-(p-dimethylaminophenyl)-4-chloro-5-cyanomethylimidazole was refluxed in a mixture of 25 ml concentrated hydrochloric acid, 25 ml water and 25 ml glacial acetic acid for 3 hours. The reaction mixture was concentrated to dryness under reduced pressure, the residue dissolved in 50 ml of water and the solution adjusted to pH 3 with sodium hydrogen carbonate. The resulting precipitate was recovered by filtration and recrystallized from aqueous ethanol. By the above procedure was obtained 4 g of 1-benzyl-2-(p-dimethylaminophenyl)-4-chloroimidazole-5-acetic acid as pale yellow needles, m.p. 170°-180° C.

Provenance & Evidence