Potassium Carbonate → 1-(p-Nitrobenzyl)-2-phenyl-4-chloro-5-formylimidazole

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Reaction Steps

In 50 ml of dimethylformamide, there were stirred 10.3 g of 2-phenyl-4-chloro-5-formylimidazole, 11.3 g of p-nitrobenzyl bromide and 5.2 g of anhydrous potassium carbonate at 110°-120° C. for 2 hours. The reaction mixture was poured in ice-water and the resulting precipitate was put on a column of 100 g silica gel, elution being carried out with chloroform. The first fraction was concentrated to dryness and recrystallized from ethanol. By the above procedure was obtained 13.6 g of 1-(p-nitrobenzyl)-2-phenyl-4-chloro-5-formylimidazole as colorless needles, m.p. 150°-152° C.

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