HCID 13746888, compound → 4-Amino-N-(1,2-diethyl-4-pyrazolidinyl)benzamide

HRID 1706400Notes

Reaction equation

HRID 1706400 reaction equation
[N+:1]([C:4]1[CH:21]=[CH:20][C:7]([C:8]([NH:10][CH:11]2[CH2:15][N:14]([CH2:16][CH3:17])[N:13]([CH2:18][CH3:19])[CH2:12]2)=[O:9])=[CH:6][CH:5]=1)([O-])=O.[H][H]>C(O)C.[Ni]>[NH2:1][C:4]1[CH:21]=[CH:20][C:7]([C:8]([NH:10][CH:11]2[CH2:12][N:13]([CH2:18][CH3:19])[N:14]([CH2:16][CH3:17])[CH2:15]2)=[O:9])=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 13746888HCID 13746888, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 104004874-Amino-N-(1,2-diethyl-4-pyrazolidinyl)benzamide

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A solution of 20 g. (0.069 mole) of 4-nitro-N-(1,2-diethyl-4-pyrazolidinyl)benzamide in ethanol was treated with Raney nickel and shaken in three atmospheres of hydrogen in a Parr apparatus at room temperature for two hours. The mixtures was filtered, the filtrate concentrated and the residue crystallized from isopropyl ether-ethyl acetate. The product (12.0 g.; 66.5%) melted at 119°-121° C.

Workup

  1. filtrationThe mixtures was filtered
  2. concentrationthe filtrate concentrated
  3. customthe residue crystallized from isopropyl ether-ethyl acetate

Sources & evidence

ORD record
ord-9c08cce90a58433cbcf1e69dbfdcaa2f
Source dataset
uspto-grants-1980_06
Patent number
US04207327

Reaction notes

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